DSIP is typically administered 30-60 minutes before bedtime to allow it to begin modulating stress hormones before sleep onset. Epithalon can be taken earlier in the evening (2-3 hours before bed) since it works on melatonin production rather than immediate sleep induction. Growth hormone peptides like Ipamorelin are best taken right before sleep to align with natural nocturnal GH pulses.
PubMed: Peptide timing considerations